Set and Setting in the Business of Psychedelics

March 24, 2025

The term “set and setting” is used frequently in the psychedelics ecosystem to indicate the intention and environment in which someone takes psychedelics.


But what does it mean in a business sense?


Psychedelics is a booming industry, and while there are many more steps to take before there is full legalization of therapeutic psychedelic use, many businesses have jumped on the bandwagon to take advantage of growing interest and accessibility.


For any new business or organization throwing their hat into the ring (and those of us that work with them), it’s important to define a healthy and ethical set and setting for psychedelic business.


For example, profit shouldn’t be the only motivator for businesses in the sector.


It’s great to make a living and a profit so you and your employees can thrive, but a profit-only motive can lead to cutting corners, disrespecting indigenous entheogenic rights, and potentially dangerous products.


Having the intention to create accessibility for those in need or to further education and awareness ensures that moving forward, your business will be aligned with best practice.


In addition, the circumstances in which you conduct business is important. 


Do you have trustworthy partnerships? 


Are you fully in line with the legality of your state?


Are you creating a positive work environment?


Set and setting takes on a whole new meaning when you apply it to the how and why of psychedelics commerce.

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